Dr. Gleghorn's Publications
Michel, L.V., Kaur, R., Gleghorn, M.L., Holmquist, M., Pryharski, K., Perdue, J., Jones, S.P., Jackson, N., Pilo, I., Kasper, A., Labbe, N., Pichichero, M. (2022) Haemophilus influenzae Protein D antibody suppression in a multi-component vaccine formulation. FEBS Open Bio. Oct 20;. doi:10.1111/feb4.13498. PMID: 36263849. PubMed link. Journal link.
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Jones, S.P.*, Cook, K.H.*, Holmquist, M.L., Almekinder, L.J., Delaney, A.M., Charles, Ryhl, Labbe, N., Perdue, J, Jackson, N., Pichichero, M.D., Kaur, R., Michel, L.V., Gleghorn, M.L. (2022) Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers. PROTEINS: Structure, Function, and Bioinformatics. PMID 36065600 PubMed link. Journal link.
*equal contribution
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Jones S.P., Goossen C., Lewis, S.D., Delaney, A.M., Gleghorn, M.L. (2022) Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase-RNA complexes. JSBX. Mar 11;6:100066. doi: 10.1016/j.yjsbx.2022.100066. PMID: 35340590 PubMed link. Journal link.
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Pickard M.A.G, Brylow K.B., Cisco L.A., Anecelle M.R., Pershun M.L., Chandrasekaran A.R., Halvorsen K., Gleghorn M.L. (2020) Parallel poly(A) homo- and hetero-duplex formation detection with an adapted DNA nanoswitch technique. RNA. May 15;. doi: 10.1261/rna.075408.120. [Epub ahead of print] PMID: 32414856. PubMed link. Journal link.
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Visentin S., Cannone G., Doutch J., Harris G., Gleghorn M.L., Clifton L., Smith B.O., Spagnolo L. (2020) A multipronged approach to understanding the form and function of hStaufen protein. RNA. Mar;26(3):265-277. doi: 10.1261/rna.072595.119. Epub 2019 Dec 18. PubMed PMID: 31852734; PubMed Central PMCID: PMC7025507. PubMed link. Journal link.
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Cho H.*, Rambout, X.*, Gleghorn, M.L.*, Nguyen, P.Q.T., Phipps, C.R., Miyoshi, K., Myers, J.R., Kataoka, N., Fasan, R., Maquat, L.E. (2018) Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes & Development. 32(7-8): 555-567. PMCID: PMC5959238 *equal contribution PubMed link. Journal link.
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“Compositions and Methods for Inhibiting CBP80 Binding to PGCI Family of Co-activators”. U.S. Patent Application No. 16/060,109, filed on June 7th, 2018
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Gleghorn M.L., Zhao J., Turner D.H., Maquat L.E. (2016) Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation. Nucl. Acids. Res. 44 (17): 8417-8424. PMCID: PMC5041459 PubMed link. Journal link.
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Gleghorn M.L. and Maquat L.E. (2014) 'Black sheep' that don't leave the double-stranded RNA-binding domain fold. Trends Biochem. Sci. 39 (7): 328-40. PMCID: PMC4077987 PubMed link. Journal link.
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Gleghorn M.L., Gong C., Kielkopf C.L., Maquat L.E. (2013) Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat. Struct. Mol. Biol. 20 (4): 515-24. PMCID: PMC4096160 PubMed link. Journal link.
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Park, E., Gleghorn, M.L., Maquat, L.E. (2013) Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U.S.A. 110 (2): 405-12. PMCID: PMC3545820 PubMed link. Journal link.
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Gleghorn, M.L., and Maquat, L.E. (2011) UPF1 Learns to Relax and Unwind. Mol Cell 41: 621-623. PMID: 21419337 PubMed link. Journal link.
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Chen, Y., Basu, R., Gleghorn, M., Murakami, K., Carey, P. (2011) Time resolved events on the reaction pathway of transcript initiation by a single subunit RNA polymerase: Raman crystallographic evidence. J. Am. Chem. Soc. 133 (32): 12544-12555. PMCID: PMC3154994 PubMed link. Journal link.
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Gleghorn, M.L., Davydova, E.K., Basu, R., Rothman-Denes, L.B., Murakami, K.S. (2011) X- ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc Natl Acad Sci U.S.A. 108: 3566-3571. PMCID: PMC3048110 PubMed link. Journal link.
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Gleghorn, M.L., Davydova, E.K., Rothman-Denes, L.B., Murakami, K.S. (2008) Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol. Cell 32:707-717. PMCID: PMC2639713 PubMed link. Journal link.